New documents strengthen—perhaps conclusively—the lab-leak hypothesis of Covid-19’s origins.

Nicholas Wade:

The day is growing ever closer when Washington may have to add to its agenda with Beijing a nettlesome item it has long sought to avoid: the increasingly likely fact that China let the SARS2 virus escape from the Wuhan lab where it was concocted, setting off the Covid-19 pandemic that killed some 7 million people globally and wrought untold economic havoc.

New documents may explain why no one has been able to find the SARS2 virus (aka SARS-CoV-2) infesting a colony of bats, from which it might have jumped to people. The reason would be that the virus has never existed in the natural world. Documents obtained by U.S. Right to Know, a health advocacy group, provide a recipe for assembling SARS-type viruses from six synthetic pieces of DNA designed to be a consensus sequence—the genetically most infectious form—of viruses related to SARS1, the bat virus that caused the minor epidemic of 2002. The probative weight of the recipe is that prior independent evidence already pointed to SARS2 having just such a six-section structure.

The documents unearthed by U.S. Right to Know, and analyzed by its reporter Emily Kopp, include drafts and planning materials for the already-known DEFUSE proposal, an application to DARPA, a Pentagon research agency, for a $14 million grant to enhance SARS-like bat viruses.

The new recipe is in striking accord with a theoretical paper published in 2022 that predicted the SARS2 virus had been generated in exactly this way. Three researchers—Valentin Bruttel, Alex Washburne, and Antonius VanDongen—noted that the virus could be cut into six sections if treated with a pair of agents known as restriction enzymes and so had probably been synthesized and assembled in this way.

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