Polygenic testing startups are Silicon Valley at its most audacious: promising to make future generations healthier and smarter, while inviting deep controversy over the soundness of the science and its potential for harm. Studies have shown that assigning “risk scores” for polygenic diseases is still a crapshoot, the results “random” and “inconsistent,” while critics claim they over-rely on data from people of European descent and offer parents a dangerous illusion of control. Hank Greely, a bioethics and law professor at Stanford University who taught Orchid founder Noor Siddiqui, said polygenic risk scores are “unproven, unprovable, unclear,” and that couples who have used them to select embryos have “wasted money.” He told me his former student Siddiqui was “very smart” but had likely “gotten ahead of her skis.”
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