Repetitive negative thinking is associated with amyloid, tau, and cognitive decline

Natalie L. Marchant, Lise R. Lovland, Rebecca Jones, Alexa Pichet Binette, Julie Gonneaud, Eider M. Arenaza-Urquijo, Gael Chételat, Sylvia Villeneuve:

The Cognitive Debt hypothesis proposes that repetitive negative thinking (RNT), a modifiable process common to many psychological risk factors for Alzheimer’s disease (AD) may itself increase risk. We sought to empirically examine relationships between RNT and markers of AD, compared with anxiety and depression symptoms.

Methods

Two hundred and ninety-two older adults with longitudinal cognitive assessments, including 113 with amyloid-positron emission tomography (PET) and tau-PET scans, from the PREVENT-AD cohort and 68 adults with amyloid-PET scans from the IMAP+ cohort were included. All participants completed RNT, anxiety, and depression questionnaires.