A bunion, you may have the misfortune to know, is a bony growth that forms at the base of your big toe. When that bump begins to irritate the rest of your foot, it has to go.
Wincing would be the correct reaction here. On the pain scale, a bunionectomy doesn’t compare to having a limb sawn off; nor is it particularly medically risky. But since it “involves shaving off extra bone and cutting the big toe in half and pinning it back together,” says David Soergel, chief medical officer of the pharmaceutical company Trevena Inc, “it’s actually a very painful surgery.” That wince-worthy quality makes it the perfect surgery on which to test cutting-edge new pain relievers—such as Oliceridine, Trevena’s newest and most promising opioid compound.