Study sheds light on how psychiatric risk gene disrupts brain development

Physorg:

A research group led by Dr. Li-Huei Tsai from the Massachusetts Institute of Technology had recently discovered that the psychiatric risk gene, Disrupted in Schizophrenia-1 (DISC1), is an essential regulator of the proliferation of early brain cells (known as neural progenitor cells) via inhibition of a molecule called GSK3? and modulation of the Wnt signaling pathway. Disruptions in the Wnt pathway, which is critical for embryonic development, have previously been linked with developmental defects and with various human diseases.

"Our recent finding was particularly interesting because one of the actions of lithium, the most common mood disorder drug, is to inhibit GSK3?." explains Dr. Tsai. "Although DISC1 was one of the first psychiatric illness risk genes to be identified and we know that it plays a key role in brain development, the mechanisms by which DISC1 is regulated remain unknown." In this study, Dr. Tsai and colleagues built on earlier work and investigated how DISC1 is regulated during cortical development by looking for novel DISC1-interacting proteins.

Posted by Jim Zellmer at July 18, 2010 1:01 AM
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