Elsy Boglioli and Magali Richard:

Advances in genetics – that began in the early 1960s – have led to continuous improvements in our understanding of DNAʼs central role in the determination of biological attributes. These advances led to numerous innovations in medicine and agriculture, such as large-scale production of insulin by bacteria for diabetic patients and plants made tolerant to herbicide to improve yield while reducing environmental footprint. This marked the entry into a new period like the first industrial revolution marked the entry into the 19th century. A second revolution began in 2000 with breakthrough advances in DNA sequencing technologies that read the information contained in DNA. This led to vast sequencing programs with the aim of sequencing the entire tree of life. It opened new areas such as personalized medicine, taking into account the genomic peculiarities of each individual.

With this easier access to DNA sequences, today we are on the verge of a third revolution that will deeply impact our lives, to the extent that computers have changed society: we are entering the era of “gene editing”, following the era of “gene reading”. Gene editing is the rational and precise modification of DNA sequences program in living cells and organisms. Why edit genes? For everything: from designing pathogen-resistant crops or therapeutic correction of defective genes responsible for diseases to rewriting the program of organisms to produce new sophisticated biologicals. The application possibilities are beyond imagination.

Not surprisingly, this new revolution has already sparked the enthusiasm of scientists and investors, with over $1 billion USD of venture-capital financing invested in emerging gene- editing technologies within the past two years.

Two recently developed technologies, Transcription Activator-Like Effector (TALE) nucleases and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) nucleases, make it possible to edit genes within a few weeks, as opposed to several months or years. Once a fully dedicated research subject, gene editing is becoming a routine manipulation in life science laboratories.

Combining accessibility with powerful potential, these technologies have already triggered ethical and legal debates. We face the usual switch from “Can we do it?” to “Should we do it?”, similar to current and past debates on other groundbreaking innovations such as human genome sequencing today or the printing press in the fifteenth century. Still we can assume that the possibilities introduced by advances in this field will drive overall acceleration and enthusiasm rather than slowdown and reluctance.
The pace of development is indeed already accelerating, driven by the amount of money invested in these technologies. The unanswered question is what will be the next safer, more efficient and more precise gene editing technology? What is certain is that gene editing is about to change our lives in many ways.